Aging and Disease
Cross-source consensus on Aging and Disease from 1 sources and 5 claims.
1 sources · 5 claims
Uses
Benefits
Evidence quality
Highlighted claims
- Stress-induced translational regulation is framed as a determinant of homeostasis, proteostasis, disease vulnerability, and aging. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Further work is needed to determine when translational repression is protective, when selective translation is required, and how modulation can avoid impairing essential protein synthesis. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Reduced translation is presented as capable of extending lifespan across multiple model organisms. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- ISRIB is cited as a pharmacological intervention that activates eIF2B, reverses effects of eIF2α phosphorylation, dissolves stress granules, and restores translation in cited studies. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Therapeutic relevance is suggested for dysregulated protein synthesis, cancer, neurodegeneration, stress maladaptation, and age-related decline. — Stress-induced Eukaryotic Translational Regulatory Mechanisms