Amino Acid Supplementation
Cross-source consensus on Amino Acid Supplementation from 2 sources and 10 claims.
2 sources · 10 claims
How it works
Dosage & preparation
Risks & contraindications
Comparisons
Evidence quality
Highlighted claims
- Serum tryptophan is not a reliable direct indicator of brain tryptophan because many amino acids compete for blood-brain barrier transport and frequently outcompete tryptophan. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
- Free-form amino acids are absorbed immediately because the liver does not need to process them, unlike whole proteins. — The #1 Danger of Prolonged Fasting
- The recommended strategy is to introduce amino acid supplementation starting on day 4 of a prolonged fast to preserve muscle while maximizing early autophagy. — The #1 Danger of Prolonged Fasting
- For cancer patients, amino acid introduction should be delayed as long as possible because certain amino acids can feed cancer cell metabolism. — The #1 Danger of Prolonged Fasting
- Low serum tryptophan indicates insufficient precursors for serotonin synthesis. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
- 5-HTP is preferred over L-tryptophan because it cannot form quinolinic or kynurenic acid and crosses the blood-brain barrier more readily. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
- Niacinamide inhibits tryptophan pyrrolase, the hepatic enzyme that breaks down tryptophan, thereby increasing the effectiveness of supplemental tryptophan. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
- Vitamin B6 deficiency directly reduces GABA production and lowers the seizure threshold. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
- A well-formulated amino acid blend has negligible caloric impact compared to whole protein, so it provides structural support without substantially interfering with fat burning or autophagy. — The #1 Danger of Prolonged Fasting
- Low GABA is common in individuals with co-occurring anxiety and depression. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions