APOL1
Cross-source consensus on APOL1 from 1 sources and 22 claims.
1 sources · 22 claims
Uses
How it works
Risks & contraindications
Background
Evidence quality
Where it comes from
Highlighted claims
- High-risk APOL1 genotypes substantially elevate the risk of progressing to end-stage kidney disease. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- APOL1 variants are associated with increased kidney disease risk, particularly in individuals of African ancestry. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- High-risk APOL1 genotypes substantially elevate the risk of progression to end-stage kidney disease. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- APOL1 risk variant expression drives kidney damage through vascular dysfunction and cellular stress. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- The link between APOL1 variants and kidney disease was established through association studies of trypanolytic APOL1 variants. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- Cell-specific expression of APOL1 high-risk variants causes both hypertension and renal injury in vivo. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- APOL1 variants are found at higher prevalence in individuals of African ancestry. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- In vivo evidence shows that cell-specific expression of APOL1 high-risk variants causes both hypertension and renal injury. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- Cell-specific expression of APOL1 high-risk variants causes both hypertension and renal injury. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
- The genetic foundation for APOL1 risk stratification was established through association studies linking trypanolytic APOL1 variants to kidney disease outcomes. — Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems