APOL1-Associated Kidney Disease Mechanisms
Cross-source consensus on APOL1-Associated Kidney Disease Mechanisms from 1 sources and 4 claims.
1 sources · 4 claims
How it works
Evidence quality
Highlighted claims
- Expression of APOL1 risk variants drives kidney damage by inducing vascular dysfunction and cellular stress. — Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals
- In vivo evidence shows that cell-specific expression of APOL1 high-risk variants causes hypertension and renal injury. — Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals
- In vivo evidence indicates that cell-specific expression of APOL1 high-risk variants causes both hypertension and renal injury. — Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals
- The kidney damage pathway is linked to systemic vascular effects. — Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals