Attractors

How it works

Comparisons

Evidence quality

Highlighted claims

• Stable cell phenotypes are treated as attractors in the regulatory network. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The epithelial attractor corresponds to an epithelial proliferative state with ESE-2, NF-kB, E2F, and Cyclin activity. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The senescent attractor corresponds to epithelial senescence with cell-cycle repression. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The mesenchymal stem-like attractor corresponds to a proliferative EMT-derived state with immortalization features. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The attractor structure was robust to random perturbations of logical rules. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis