BCL-2
Cross-source consensus on BCL-2 from 1 sources and 5 claims.
1 sources · 5 claims
How it works
Preparation
Evidence quality
Highlighted claims
- Antiapoptotic BCL-2 family proteins at mitochondria oppose mitochondrial apoptosis, while BH3-only proteins promote it. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
- For population simulations, mitochondrial BCL-2 was sampled from a lognormal distribution to represent heterogeneous apoptotic thresholds. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
- BCL-2 overexpression was simulated by tripling ER and mitochondrial BCL-2. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
- The model captured the observation that BCL-2 overexpression suppresses basal and cisplatin-induced autophagy. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
- Excess ER BCL-2 prevents autophagy initiation by binding Beclin-1, while excess mitochondrial BCL-2 prevents BH3 from crossing the apoptotic threshold. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells