Bioidentical Hormone Therapy

Uses

How it works

Benefits

Dosage & preparation

Risks & contraindications

Evidence quality

Highlighted claims

• The Women's Health Initiative studied synthetic hormones, not bioidentical hormones, so its findings do not transfer directly to bioidentical hormone therapy. — Five Clinical Biohacks for Perimenopause and Menopause
• Bioidentical hormone therapy is available in multiple delivery forms including transdermal, injectable, patch, pellet, and oral routes. — Five Clinical Biohacks for Perimenopause and Menopause
• Because bioidentical hormones share an identical chemical structure with endogenous hormones, the body's enzymatic machinery processes them through established metabolic pathways. — Five Clinical Biohacks for Perimenopause and Menopause
• Upon re-evaluation of WHI data, the initial finding of increased breast cancer risk was not upheld; the revised analysis showed no increased risk above individual baseline. — Five Clinical Biohacks for Perimenopause and Menopause
• NAMS 2022–2023 position statements conclude hormone therapy decreases all morbidity and all mortality in appropriately selected women. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• The breast cancer signal in the WHI was limited to the synthetic progestin arm, not the bioidentical progesterone arm. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• Oral estrogen delivery is avoided entirely in favor of transdermal patch or intravaginal application to bypass first-pass liver metabolism. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• Women using synthetic progestin in oral contraceptives for 15 or more years have a 39% increased risk of breast cancer. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• Testosterone is used in approximately 80% of menopause cases, supporting muscle mass, libido, intravaginal tissue health, and cognitive function. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• Women more than 10 years into menopause without prior hormone therapy face uncertain cardioprotective benefit from initiating HRT, though cognitive support may still apply. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide