Biomarkers and Assessments
Cross-source consensus on Biomarkers and Assessments from 1 sources and 4 claims.
1 sources · 4 claims
Uses
How it works
Evidence quality
Highlighted claims
- Transient elastography is used as a non-invasive surrogate marker of liver fibrosis. — Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid
- OPERA explores mechanistic biomarkers related to biliary epithelial cell senescence. — Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid
- The optional biopsy sub-study directly assesses OCA effects on bile duct injury and cellular senescence. — Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid
- A composite chemokine marker using circulating CCL20 and CXCL11 will be validated against clinical outcomes and liver biopsy assessment. — Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid