Biomarkers and Genetics

Preparation

Other

Other

Highlighted claims

• The planned serum biomarker panel includes GFAP, NfL, total tau, and UCH-L1. — PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery – protocol for an international, multicentre, prospective cohort study
• Blood samples are collected at multiple perioperative and follow-up timepoints. — PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery – protocol for an international, multicentre, prospective cohort study
• Serum aliquots are stored at -80°C within 2 hours after collection processing. — PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery – protocol for an international, multicentre, prospective cohort study
• Genotyping uses the Infinium Global Screening Array with multi-disease drop on an automated iScan System. — PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery – protocol for an international, multicentre, prospective cohort study
• A genome-wide association study will explore genetic variants or candidate genes linked to brain injury risk after cardiac surgery. — PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery – protocol for an international, multicentre, prospective cohort study
• The final biomarker platform and possible additional markers will be selected after recruitment ends based on available technology. — PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery – protocol for an international, multicentre, prospective cohort study