Brain Inflammation
Cross-source consensus on Brain Inflammation from 3 sources and 16 claims.
3 sources · 16 claims
How it works
Benefits
Risks & contraindications
Evidence quality
Highlighted claims
- Chronic stress dysregulates the HPA axis, leading to increased blood-brain barrier permeability. — Neuroinflammation and Treatment-Resistant Depression
- Once peripheral inflammatory markers enter the CNS, microglia activate and produce quinolinic acid and other neurotoxic mediators damaging mood and cognition circuits. — Neuroinflammation and Treatment-Resistant Depression
- Serotonin, dopamine, and norepinephrine deficits in depression are downstream outputs of inflammatory dysregulation, not primary deficits. — Neuroinflammation and Treatment-Resistant Depression
- Advanced TRD interventions produce downstream healthcare costs 4.3 times higher than standard care. — Neuroinflammation and Treatment-Resistant Depression
- Sugar and refined starch are the primary drivers of insulin resistance and visceral fat accumulation, making the standard Western diet directly brain-inflammatory. — Food as Medicine for the Brain: Gut, Microbiome, and Mental Health
- Neuroinflammation is a common denominator across schizophrenia, autism spectrum disorder, major depression, bipolar disorder, and OCD. — Food as Medicine for the Brain: Gut, Microbiome, and Mental Health
- Visceral fat cells produce adipokines — inflammatory cytokines — that travel systemically to the brain and disrupt neural function. — Food as Medicine for the Brain: Gut, Microbiome, and Mental Health
- Recovery from neuroinflammatory depression is biologically impossible under sustained sympathetic nervous system dominance. — Neuroinflammation and Treatment-Resistant Depression
- Ultra-processed food additives require active liver and kidney detoxification, diverting energy from higher cognition and triggering additional inflammatory cascades. — Food as Medicine for the Brain: Gut, Microbiome, and Mental Health
- TNF-alpha blockers have been explored experimentally for depression because depression involves TNF-alpha-mediated inflammation, validating the inflammatory mechanism. — Food as Medicine for the Brain: Gut, Microbiome, and Mental Health