Brain Penetrance

How it works

Comparisons

Evidence quality

Highlighted claims

• Brain penetrability was quantified using Kp,uu,brain, derived from animal studies measuring free drug concentrations in rat plasma and brain tissue after intravenous dosing. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
• A strength of the study was direct measurement of brain penetrability for each CCB, rather than relying on previously published penetrance classifications measured with inconsistent methods. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
• The study conclusion does not exclude the possibility that CCB formulations or doses specifically designed to target the brain could still have neuropsychiatric effects. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study