CaV1.2 / CACNA1C
Cross-source consensus on CaV1.2 / CACNA1C from 1 sources and 4 claims.
1 sources · 4 claims
How it works
Background
Evidence quality
Highlighted claims
- CaV1.2 is encoded by the CACNA1C gene and mediates calcium signalling in neurons. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
- CACNA1C SNPs have been identified in genome-wide association studies spanning schizophrenia, bipolar disorder, major depression, ADHD, and autism. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
- CaV1.2 contributes to neuronal survival, dendritic development, synaptic plasticity, learning, memory, and behaviour. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
- Whether CACNA1C risk variants produce gain-of-function or loss-of-function effects remains uncertain, making the direction of therapeutic intervention unclear. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study