CD38
Cross-source consensus on CD38 from 1 sources and 4 claims.
1 sources · 4 claims
How it works
Risks & contraindications
Highlighted claims
- CD38 is extraordinarily metabolically expensive, requiring 100 NAD molecules to produce a single downstream signaling molecule. — NAD Decline, Salvage Pathway Failure, and Systems-Based Restoration
- CD38 upregulation is driven by cellular senescence through pro-inflammatory SASP signaling. — NAD Decline, Salvage Pathway Failure, and Systems-Based Restoration
- CD38 and cellular senescence form a self-reinforcing cycle that accelerates NAD depletion by impairing the repair systems that would otherwise clear senescent cells. — NAD Decline, Salvage Pathway Failure, and Systems-Based Restoration
- Aging increases DNA repair demand at precisely the moment NAD availability is lowest, compounding the deficit. — NAD Decline, Salvage Pathway Failure, and Systems-Based Restoration