Celiac Disease

How it works

Benefits

Risks & contraindications

Evidence quality

Highlighted claims

• Celiac disease affects approximately 0.5–1% of the global population and is a non-IgE-mediated autoimmune disease triggered by gluten. — Food Reactions and Mood: Mechanisms, Evidence, and the Gut-Brain Axis
• Celiac disease produces autoantibodies including tissue transglutaminase 6 expressed in the brain and anti-gliadin antibodies implicated in neurologic and psychiatric disease. — Food Reactions and Mood: Mechanisms, Evidence, and the Gut-Brain Axis
• Celiac disease causes inflammation of the small intestinal lining due to gluten sensitivity, impairing nutrient absorption. — The Difference Between the Small Intestine and the Large Intestine
• Celiac disease can lead to widespread nutritional deficiencies because the small intestine is responsible for 90% of digestion and absorption. — The Difference Between the Small Intestine and the Large Intestine
• The celiac disease to depression pathway is the best-evidenced food-mood connection. — Food Reactions and Mood: Mechanisms, Evidence, and the Gut-Brain Axis
• Adolescents with undiagnosed celiac disease had measurably low free tryptophan levels, the amino acid precursor to serotonin. — Food Reactions and Mood: Mechanisms, Evidence, and the Gut-Brain Axis
• Impaired tryptophan availability in untreated celiac adolescents is a primary mechanism driving depression and behavioral dysregulation. — Food Reactions and Mood: Mechanisms, Evidence, and the Gut-Brain Axis
• A gluten-free diet in celiac adolescents decreased celiac-specific antibodies, indicating a calming of the immune response. — Food Reactions and Mood: Mechanisms, Evidence, and the Gut-Brain Axis