Cisplatin

Cross-source consensus on Cisplatin from 1 sources and 5 claims.

1 sources · 5 claims

Uses

The model stress variable C represents cisplatin or another stressor, with C = 20 scaled to 20 uM cisplatin in the main fitted experiments. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
In an average cell exposed to C = 20, autophagy activated early and caspases activated at 18 hours. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
The mapping between cisplatin dose and model stress C is not assumed to be linear. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
In cisplatin nephrotoxicity, the framework emphasizes that autophagy may protect normal kidney cells, so inhibiting autophagy could worsen normal-tissue injury. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
The model suggests extending apoptosis measurements to 24 hours and beyond under high cisplatin stress to test predicted eventual apoptotic commitment. — Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells