Coagulation and Immune-Thrombosis Mechanisms

Uses

How it works

Preparation

Evidence quality

Highlighted claims

• The trial measures immune-thrombosis biomarkers including MPO-DNA complex and citrullinated histone H3 as secondary outcomes. — Effect of preoperative liposomal bupivacaine single-injection pericapsular nerve group (PENG) block on lower extremity deep vein thrombosis in elderly patients with hip fractures: a randomised controlled, double-blind, prospective clinical study protocol
• MPO-DNA complexes and citrullinated histone H3 are quantified using ELISA kits, while other biomarkers are analyzed by the hospital central laboratory. — Effect of preoperative liposomal bupivacaine single-injection pericapsular nerve group (PENG) block on lower extremity deep vein thrombosis in elderly patients with hip fractures: a randomised controlled, double-blind, prospective clinical study protocol
• Adequate analgesia is being tested as a way to reduce hypercoagulability and immobility, not only as pain control. — Effect of preoperative liposomal bupivacaine single-injection pericapsular nerve group (PENG) block on lower extremity deep vein thrombosis in elderly patients with hip fractures: a randomised controlled, double-blind, prospective clinical study protocol
• Preoperative hip-fracture pain can intensify systemic inflammatory and stress responses, promoting thrombosis through tissue factor activation and neutrophil extracellular trap formation. — Effect of preoperative liposomal bupivacaine single-injection pericapsular nerve group (PENG) block on lower extremity deep vein thrombosis in elderly patients with hip fractures: a randomised controlled, double-blind, prospective clinical study protocol
• Cochrane evidence associates peripheral nerve block with shorter time to first postoperative mobilization, which may help reduce DVT risk. — Effect of preoperative liposomal bupivacaine single-injection pericapsular nerve group (PENG) block on lower extremity deep vein thrombosis in elderly patients with hip fractures: a randomised controlled, double-blind, prospective clinical study protocol