COMBINE Trial

Cross-source consensus on COMBINE Trial from 1 sources and 5 claims.

1 sources · 5 claims

Uses

The COMBINE trial is a prospective randomised two-arm open-label blinded-endpoint efficacy trial in Leicester, UK. — Combining structured exercise with a low-energy diet to attenuate lean mass loss in South Asian adults living with type 2 diabetes: the COMBINE randomised trial protocol
The trial tests whether adding structured exercise to a meal-replacement-based low-energy diet reduces lean mass loss in South Asian adults with type 2 diabetes and excess adiposity. — Combining structured exercise with a low-energy diet to attenuate lean mass loss in South Asian adults living with type 2 diabetes: the COMBINE randomised trial protocol
The primary objective is to compare lean mass change between intervention groups using DXA at baseline and 12 weeks. — Combining structured exercise with a low-energy diet to attenuate lean mass loss in South Asian adults living with type 2 diabetes: the COMBINE randomised trial protocol
The trial plans to enrol 36 participants with 18 assigned to each arm and a target of 32 completers. — Combining structured exercise with a low-energy diet to attenuate lean mass loss in South Asian adults living with type 2 diabetes: the COMBINE randomised trial protocol
The study is in follow-up, with the latest approved protocol version 2.3 dated 12 June 2025. — Combining structured exercise with a low-energy diet to attenuate lean mass loss in South Asian adults living with type 2 diabetes: the COMBINE randomised trial protocol