Cortical Spreading Depolarisations

How it works

Risks & contraindications

Highlighted claims

• Cortical spreading depolarisations are pathological waves of neuronal and glial depolarisation across the cortex. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• Cortical spreading depolarisations are implicated in migraine aura, transient focal neurologic episodes, microinfarct development in CAA, and secondary damage after stroke. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• Mouse research showed that cortical spreading depolarisations rapidly close perivascular spaces around surface and penetrating vessels. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• Perivascular spaces remain partially constricted for at least 30 minutes after closure from cortical spreading depolarisations. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• Dye movement from cortex into perivascular spaces is reduced during closure caused by cortical spreading depolarisations. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial