COSI-2 Trial

Cross-source consensus on COSI-2 Trial from 1 sources and 5 claims.

1 sources · 5 claims

Comparisons

COSI-2 is a pragmatic, cluster-randomised, two-arm, parallel-group, multicentre phase III clinical trial. — Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol
COSI-2 compares topical coconut oil plus routine skin care with routine skin care alone. — Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol
Recruitment ran from March 1, 2022 to August 31, 2024, and intervention continued until the final NICU discharge in January 2025. — Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol
The trial cannot be blinded because coconut oil has a distinct fragrance and no approved safe placebo is available. — Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol
Neonatal units are randomised as clusters to test real-world unit-level implementation, avoid contamination, and make routine care changes practical. — Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol