Cytochrome P450 Enzymes

How it works

Benefits

Risks & contraindications

Interactions

Evidence quality

Highlighted claims

• There are over 2,000 known mutations of the cytochrome P450 gene. — Eliminating the SIDE EFFECTS of Medication
• Phase 1 detoxification is carried out by cytochrome P450 enzymes located primarily in the liver. — Best Meal for Liver Detoxification
• Cytochrome P450 enzymes initiate drug breakdown by chemically transforming the drug or toxin, often making it temporarily more reactive. — Eliminating the SIDE EFFECTS of Medication
• CYP450 gene mutations can produce poor metabolizers whose drugs accumulate and amplify side effects, or ultra-rapid metabolizers whose drugs break down too fast to be effective. — Eliminating the SIDE EFFECTS of Medication
• During Phase 1, the activated intermediate becomes more toxic and more carcinogenic than the original compound. — Best Meal for Liver Detoxification
• Grapefruit inhibits cytochrome P450 enzymes, causing medications to remain in the system longer and accumulate to toxic levels. — Best Meal for Liver Detoxification
• The Phase 1 oxidation process produces highly reactive intermediates and a large free radical load. — Best Meal for Liver Detoxification
• Dietary antioxidants protect liver cells from the oxidative damage generated during Phase 1. — Best Meal for Liver Detoxification
• Most medications work by inhibiting specific enzymes, such as ACE inhibitors blocking angiotensin-converting enzyme and aspirin inhibiting COX enzymes. — Eliminating the SIDE EFFECTS of Medication
• Enzymes require vitamins and minerals as cofactors to function, so micronutrient deficiency impairs the body's entire enzymatic infrastructure. — Eliminating the SIDE EFFECTS of Medication