Dabi-SNAP trial

Uses

Risks & contraindications

Where it comes from

Other

Highlighted claims

• Dabi-SNAP is a nested domain within the SNAP adaptive platform trial. — Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial
• Dabi-SNAP is an open-label phase 4 comparative effectiveness trial with 1:1 randomisation. — Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial
• The trial enrolls adults already enrolled in SNAP who are taking or imminently starting an oral FXa inhibitor for an approved indication. — Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial
• The current-user design is intended to improve validity and participant safety because participants have already tolerated anticoagulation. — Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial
• Patients already receiving dabigatran are excluded partly to avoid potential harm from switching them to an FXa inhibitor if dabigatran is beneficial. — Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial