DESTINATION 2 Trial

Cross-source consensus on DESTINATION 2 Trial from 1 sources and 5 claims.

1 sources · 5 claims

Uses

The trial plans to recruit 200 patients worldwide with 100 assigned to each treatment arm. — Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial
DESTINATION 2 is an international federated randomized open-label phase II/R-IDEAL 2b trial for men with localized MRI-visible prostate cancer. — Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial
The trial tests whether de-escalating dose to benign-appearing prostate tissue while maintaining tumoricidal dose to visible tumor can reduce genitourinary adverse events without compromising disease control. — Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial
The central hypothesis is that de-escalated two-fraction prostate SBRT will reduce acute grade 2 or higher genitourinary adverse events compared with uniform-dose two-fraction SBRT. — Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial
Both treatment arms are experimental because optimal MRI-guided two-fraction SBRT regimens are not established. — Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial