DNA and Genetics

Uses

How it works

Risks & contraindications

Comparisons

Evidence quality

Where it comes from

Highlighted claims

• An extended deep dive into DNA and genetic variation is in progress. — We Just Hit 10,000,000 Subscribers!
• The genetics content will explain what different gene variants (SNPs and other mutations) mean for individual health in simple, actionable terms. — We Just Hit 10,000,000 Subscribers!
• The MTHFR C677T SNP is present in up to 20% of the general population; homozygous carriers lose 40–70% of enzyme function. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
• An MTHFR SNP reduces activated folate availability, which ultimately reduces serotonin precursor availability because tryptophan hydroxylase 2 requires activated folate as a cofactor. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
• A SNP in the tryptophan hydroxylase 2 gene can cause up to 80% loss of serotonin biosynthetic function at the rate-limiting step. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
• SNPs that increase MAO enzyme activity accelerate catecholamine breakdown in the CNS, increasing depression incidence. — Functional Medicine Approach to Depression: Biomarkers, SNPs, and Therapeutic Interventions
• Variants in genes involved in B12 absorption, conversion, or activation can significantly impair B12 uptake even with adequate dietary intake. — 6 Causes of a Vitamin B12 Deficiency You've Never Heard Before
• Methylcobalamin is preferred over cyanocobalamin for people with SNPs affecting B12 conversion, since cyanocobalamin requires the enzymatic conversion that the SNP impairs. — 6 Causes of a Vitamin B12 Deficiency You've Never Heard Before
• Red meat and beef liver are among the foods highest in natural B12. — 6 Causes of a Vitamin B12 Deficiency You've Never Heard Before
• The learning curve for genetics content is substantial, requiring deep understanding before simple explanations can be produced. — We Just Hit 10,000,000 Subscribers!