eIF4F/eIF4E Axis
Cross-source consensus on eIF4F/eIF4E Axis from 1 sources and 4 claims.
1 sources · 4 claims
How it works
Highlighted claims
- During stress, mTORC1 inhibition causes 4EBP dephosphorylation, allowing 4EBP to bind eIF4E and repress cap-dependent translation. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- The eIF4F/eIF4E axis is presented as a major initiation-control system during stress. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Under favorable conditions, mTORC1 phosphorylation of 4EBPs prevents 4EBPs from binding eIF4E and permits eIF4F assembly. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Mnk1/Mnk2 phosphorylation of eIF4E is associated with selective translation of mRNAs linked to survival, angiogenesis, proliferation, tumor progression, and stress tolerance. — Stress-induced Eukaryotic Translational Regulatory Mechanisms