Empirical Calibration

How it works

Highlighted claims

• The study used 180 negative control outcomes to detect and correct for residual systematic error in hazard ratio estimates. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
• Only empirically calibrated results were reported. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
• Effect estimates from databases passing diagnostics were pooled using Bayesian random-effects meta-analysis with non-normal likelihood approximation to reduce bias from small event counts. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study
• Cox proportional hazards models conditioned on propensity score matching strata estimated calibrated hazard ratios, which were reported with 95% confidence intervals and p values. — Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study