Epithelial Carcinogenesis

How it works

Evidence quality

Highlighted claims

• The model is not presented as a quantitative predictor of carcinoma occurrence or future tumor behavior. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The article frames epithelial carcinogenesis as a developmental-like dynamical process governed by gene regulatory network constraints. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The article proposes that replicative senescence and chronic inflammation may promote epithelial carcinogenesis by increasing spontaneous immortalization in vivo, but this needs further testing. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The model cautiously proposes that the same cell-state transitions observed in vitro may occur during epithelial carcinogenesis in vivo. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis