Excitatory Amino Acid Inhibitors

Uses

Benefits

Comparisons

Evidence quality

Highlighted claims

• Nine EAA inhibitors were evaluated in the included trials. — Excitatory amino acid inhibitors in adults with acute moderate to severe traumatic brain injury: a systematic review and meta-analysis
• Early EAA inhibitor use was evaluated as an acute treatment for adults with moderate to severe traumatic brain injury. — Excitatory amino acid inhibitors in adults with acute moderate to severe traumatic brain injury: a systematic review and meta-analysis
• The clinical evidence base included NMDA-targeting ionotropic glutamate receptor antagonists and magnesium sulfate, while other EAA inhibitor classes have not yet been evaluated in humans with TBI. — Excitatory amino acid inhibitors in adults with acute moderate to severe traumatic brain injury: a systematic review and meta-analysis
• The review does not establish EAA inhibitors as effective acute neuroprotective therapy for moderate to severe TBI. — Excitatory amino acid inhibitors in adults with acute moderate to severe traumatic brain injury: a systematic review and meta-analysis
• EAA inhibitors are not currently guideline-recommended for acute moderate to severe TBI because clinical evidence has been mixed. — Excitatory amino acid inhibitors in adults with acute moderate to severe traumatic brain injury: a systematic review and meta-analysis