Folate
Cross-source consensus on Folate from 1 sources and 6 claims.
1 sources · 6 claims
How it works
Benefits
Dosage & preparation
Risks & contraindications
Highlighted claims
- Folic acid is synthetic and must be converted to L-methylfolate before it can act in the brain. — Homocysteine, B Vitamins, and Mental Health: A Functional Psychiatry Framework
- L-methylfolate is described as the only folate form directly active in the central nervous system. — Homocysteine, B Vitamins, and Mental Health: A Functional Psychiatry Framework
- Low folate status is associated with higher depression rates and poorer antidepressant response. — Homocysteine, B Vitamins, and Mental Health: A Functional Psychiatry Framework
- High-dose L-methylfolate has evidence for antidepressant augmentation but may cause anxiety and agitation. — Homocysteine, B Vitamins, and Mental Health: A Functional Psychiatry Framework
- The article recommends starting L-methylfolate at 400–800 mcg and titrating cautiously. — Homocysteine, B Vitamins, and Mental Health: A Functional Psychiatry Framework
- Folate supplementation may enhance the antidepressant effect of medication. — Homocysteine, B Vitamins, and Mental Health: A Functional Psychiatry Framework