Framework Limitations

Risks & contraindications

Evidence quality

Highlighted claims

• The framework does not report a new empirical cohort or prospective validation of the prognostic score. — Disease Is a Spectral Perturbation
• The optimality theorem depends on restrictive assumptions that may not hold for many clinical biomarkers. — Disease Is a Spectral Perturbation
• High-dimensional settings with more biomarkers than samples create rank deficiency in the Hamiltonian. — Disease Is a Spectral Perturbation
• The formalism is currently static and would need time-varying Hamiltonians for longitudinal disease progression. — Disease Is a Spectral Perturbation