Gene Network Stability

How it works

Comparisons

Highlighted claims

• The stability condition depends on the ratio of regulatory defect propagation to repair and turnover capacity. — Stability analysis of a model gene network links aging, stress resistance and negligible senescence
• The model treats aging as accumulation of epigenetic or regulatory errors in a genetic network. — Stability analysis of a model gene network links aging, stress resistance and negligible senescence
• Ordinary aging is interpreted as instability in coupled genome-expressome regulatory networks. — Stability analysis of a model gene network links aging, stress resistance and negligible senescence
• The model predicts larger lifespan effects from changing the stability exponent than from lowering stress alone. — Stability analysis of a model gene network links aging, stress resistance and negligible senescence