Gene Regulatory Network Model
Cross-source consensus on Gene Regulatory Network Model from 1 sources and 5 claims.
1 sources · 5 claims
Preparation
Evidence quality
Highlighted claims
- The final core Boolean network had nine nodes: ESE-2, Snai2, NF-kB, E2F, p53, p16, Rb, Cyclin, and Telomerase. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- The large curated gene regulatory network contained 41 nodes and 97 experimentally supported interactions. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- The reduced Boolean model recovered exactly three fixed-point attractors that matched expected biological phenotypes. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- The network reflects literature and curation choices available before 2014. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- The model uses published experimental interactions rather than hypothetical regulatory edges. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis