Genomic Integration

Risks & contraindications

Evidence quality

Highlighted claims

• A rare case linked genomic integration of an AAV gene therapy vector to tumor development. — A rare case of gene therapy-linked cancer
• AAV integration can occur even though AAV vectors are generally considered non-integrating. — A rare case of gene therapy-linked cancer
• The reported case involved rare genomic integration of an adenovirus-associated vector linked to tumor formation. — A rare case of gene therapy-linked cancer
• The case shows that generally non-integrating vector systems can still integrate in rare circumstances. — A rare case of gene therapy-linked cancer