Gut Function Outcome Measures

Uses

How it works

Evidence quality

Highlighted claims

• The lactulose/rhamnose dual-sugar test is the primary functional assay for intestinal permeability in the trials. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• The dual stable isotope test measures the fraction of protein-derived amino acids from a meal that enter systemic circulation. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• The ¹³C sucrose breath test assesses sucrase-isomaltase activity, which is suppressed in environmental enteropathy. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• Plasma iFABP and LPSBP are measured because both are elevated in environmental enteropathy. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• Faecal MPO and neopterin are used as markers of neutrophil activation and interferon-gamma-mediated macrophage activation. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• Complete protein digestion and absorption in the DSIT is indicated when plasma amino acid isotope ratios match the test meal ratio. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials