IL-17/IL-23 Pathway

Cross-source consensus on IL-17/IL-23 Pathway from 1 sources and 0 claims.

1 sources · 0 claims

How it works

Th17 cells are activated by IL-1β, IL-6, IL-23, and TGF-β via the STAT3 pathway, producing IL-17A/F and IL-22. — Psoriasis as a Gut-Driven Systemic Disease: Root Causes, Immune Pathways, and Naturopathic Treatment
The net immune result in psoriasis is excessive Th1 and Th17 activity combined with insufficient Treg activity. — Psoriasis as a Gut-Driven Systemic Disease: Root Causes, Immune Pathways, and Naturopathic Treatment
The IL-17/IL-23 axis is the dominant immune pathway in psoriasis, identified around 2005 and driving the development of targeted biologic therapies. — Psoriasis as a Gut-Driven Systemic Disease: Root Causes, Immune Pathways, and Naturopathic Treatment
T-regulatory cells are under-activated in psoriasis, failing in their normal function of suppressing inflammation and maintaining immune tolerance. — Psoriasis as a Gut-Driven Systemic Disease: Root Causes, Immune Pathways, and Naturopathic Treatment