Immunobridging

Uses

Comparisons

Highlighted claims

• Immunobridging studies compare immune responses from investigational regimens with responses from approved regimens. — Efficient estimation of cumulative incidence curves via data fusion with surrogates: application to integrated analysis of vaccine trial and immunobridging data
• The paper studies vaccine settings where updated regimens may be authorized without new large efficacy trials. — Efficient estimation of cumulative incidence curves via data fusion with surrogates: application to integrated analysis of vaccine trial and immunobridging data
• The framework is intended to estimate clinical incidence and relative vaccine efficacy curves, not only immune response differences. — Efficient estimation of cumulative incidence curves via data fusion with surrogates: application to integrated analysis of vaccine trial and immunobridging data
• Regulatory or scientific immunobridging analyses can use the framework when immune correlates are validated and assumptions are credible. — Efficient estimation of cumulative incidence curves via data fusion with surrogates: application to integrated analysis of vaccine trial and immunobridging data