INBUGS-NG Cohort Design

Uses

Comparisons

Background

Evidence quality

Highlighted claims

• The study was embedded as a substudy of BARNARDS-II, which investigates neonatal sepsis and antibiotic resistance across multiple low- and middle-income countries. — Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG)
• INBUGS-NG is a prospective longitudinal cohort following mother-infant dyads from birth through 12 months in northern Nigeria. — Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG)
• The study collected infant stool at 10 scheduled time points during the first year, with additional intensified sampling after infant antibiotic exposure. — Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG)
• Of 90 enrolled dyads, 87 had baseline biological samples, and 79 remained in active follow-up by day 90, representing 91% retention. — Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG)
• The small sample size limits statistical power for stratified analyses of subgroups such as caesarean deliveries, exclusively breastfed infants, and antibiotic-exposed infants. — Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG)
• A parallel comparison with the Pakistan cohort INBUGS-P is planned to distinguish setting-specific features from shared patterns in early-life microbiome development. — Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG)
• INBUGS-NG is described as one of the first prospective longitudinal African infant cohorts to combine infant, maternal, breast milk, and environmental sampling with long-read shotgun metagenomics. — Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG)