Intraluminal Colonic Pressure

How it works

Background

Evidence quality

Highlighted claims

• The DIPHYSIO investigators extend the intraluminal pressure hypothesis by focusing on defecatory technique. — Pilot multicentre open-label randomised controlled trial assessing prevention of recurrent DIverticulitis through the use of pelvic floor PHYSIOtherapy: DIPHYSIO study protocol
• Evidence for elevated intraluminal pressure as a causative factor in diverticular disease has been inconsistent. — Pilot multicentre open-label randomised controlled trial assessing prevention of recurrent DIverticulitis through the use of pelvic floor PHYSIOtherapy: DIPHYSIO study protocol
• The broader literature on intraluminal pressure is described as sparse and methodologically heterogeneous. — Pilot multicentre open-label randomised controlled trial assessing prevention of recurrent DIverticulitis through the use of pelvic floor PHYSIOtherapy: DIPHYSIO study protocol
• Studies from the 1960s identified exaggerated pressure responses in diverticulosis patients compared with controls under gastrocolic reflex or pharmacological stimulation conditions. — Pilot multicentre open-label randomised controlled trial assessing prevention of recurrent DIverticulitis through the use of pelvic floor PHYSIOtherapy: DIPHYSIO study protocol
• A contemporary high-resolution manometry study by Jaung et al. did not find a statistically significant pressure difference. — Pilot multicentre open-label randomised controlled trial assessing prevention of recurrent DIverticulitis through the use of pelvic floor PHYSIOtherapy: DIPHYSIO study protocol