Intranasal Dexmedetomidine

Uses

Benefits

Comparisons

Evidence quality

Highlighted claims

• Intranasal dexmedetomidine is being evaluated as a perioperative treatment for sleep disturbance. — Intranasal dexmedetomidine for perioperative sleep disturbance: a protocol for a systematic review with meta-analysis and trial sequential analysis
• Intranasal delivery avoids venipuncture and intramuscular injection pain. — Intranasal dexmedetomidine for perioperative sleep disturbance: a protocol for a systematic review with meta-analysis and trial sequential analysis
• Intranasal dexmedetomidine has practical administration advantages including high bioavailability, simplicity, convenience, and no mucosal irritation. — Intranasal dexmedetomidine for perioperative sleep disturbance: a protocol for a systematic review with meta-analysis and trial sequential analysis
• Evidence for intranasal dexmedetomidine remains uncertain because existing studies are small, diverse, and inconsistent in quality. — Intranasal dexmedetomidine for perioperative sleep disturbance: a protocol for a systematic review with meta-analysis and trial sequential analysis
• Intranasal dexmedetomidine has a slower onset and a more favorable cardiovascular safety profile than IV bolus administration. — Intranasal dexmedetomidine for perioperative sleep disturbance: a protocol for a systematic review with meta-analysis and trial sequential analysis
• Intranasal dexmedetomidine has shown benefits for anxiety-related insomnia, chronic insomnia, pediatric refractory sleep disturbance, and sleep disorders in elderly general anesthesia patients. — Intranasal dexmedetomidine for perioperative sleep disturbance: a protocol for a systematic review with meta-analysis and trial sequential analysis