Labile Iron

How it works

Highlighted claims

• Labile iron is the redox-active, weakly chelated iron fraction most relevant to oxidative injury. — Evaluation of the performance and safety of adding the iron chelator MEX-CD1 to dialysate during continuous veno-venous haemodialysis for removing excess labile iron in intensive care patients with sepsis-associated acute kidney injury - the Iron in Intensive Care trial (IRON-I.C.): protocol for a p
• Excess labile iron can generate hydroxyl radicals and reactive oxygen species through Fenton and Haber-Weiss reactions. — Evaluation of the performance and safety of adding the iron chelator MEX-CD1 to dialysate during continuous veno-venous haemodialysis for removing excess labile iron in intensive care patients with sepsis-associated acute kidney injury - the Iron in Intensive Care trial (IRON-I.C.): protocol for a p
• During severe sepsis and septic shock, protective iron-sequestering mechanisms can be overwhelmed. — Evaluation of the performance and safety of adding the iron chelator MEX-CD1 to dialysate during continuous veno-venous haemodialysis for removing excess labile iron in intensive care patients with sepsis-associated acute kidney injury - the Iron in Intensive Care trial (IRON-I.C.): protocol for a p
• Oxidative damage from labile iron is presented as contributing to systemic inflammation, multiorgan dysfunction, and acute kidney injury. — Evaluation of the performance and safety of adding the iron chelator MEX-CD1 to dialysate during continuous veno-venous haemodialysis for removing excess labile iron in intensive care patients with sepsis-associated acute kidney injury - the Iron in Intensive Care trial (IRON-I.C.): protocol for a p