Maternal Thyroid Function

How it works

Comparisons

Evidence quality

Where it comes from

Highlighted claims

• Thyroid hormone is critical for fetal growth and basal metabolic regulation. — Association between age-specific preconception thyroid-stimulating hormone (TSH) and birth weight: a retrospective study
• During early pregnancy, before the fetal thyroid matures, the fetus depends almost entirely on maternal thyroid hormones transferred across the placenta. — Association between age-specific preconception thyroid-stimulating hormone (TSH) and birth weight: a retrospective study
• Hyperthyroidism is conventionally associated with SGA rather than LGA, making the elevated LGA risk observed at low TSH counterintuitive. — Association between age-specific preconception thyroid-stimulating hormone (TSH) and birth weight: a retrospective study
• An estimated 30–50% of newborn thyroxine (T4) concentrations derive from maternal sources alone. — Association between age-specific preconception thyroid-stimulating hormone (TSH) and birth weight: a retrospective study
• Maternal hypothyroidism and subclinical hypothyroidism promote fetal hyperinsulinaemia and excessive intrauterine growth via insulin resistance and dyslipidaemia, resulting in LGA. — Association between age-specific preconception thyroid-stimulating hormone (TSH) and birth weight: a retrospective study
• Prior meta-analyses found that each 1 SD increase in maternal TSH is associated with approximately 6 g lower birth weight on average. — Association between age-specific preconception thyroid-stimulating hormone (TSH) and birth weight: a retrospective study