Megestrol Acetate

Uses

How it works

Dosage & preparation

Evidence quality

Highlighted claims

• In this trial, megestrol acetate is given orally once daily at 160 mg on days 1 through 3. — Megestrol acetate versus dexamethasone to prevent nausea and vomiting in patients with gastric or gastro-oesophageal junction cancer treated with oxaliplatin-based chemotherapy: study protocol of a multicentre, randomised, non-inferiority trial
• Megestrol acetate is a synthetic progestin used clinically to improve cancer-related anorexia and cachexia. — Megestrol acetate versus dexamethasone to prevent nausea and vomiting in patients with gastric or gastro-oesophageal junction cancer treated with oxaliplatin-based chemotherapy: study protocol of a multicentre, randomised, non-inferiority trial
• Earlier evidence suggests megestrol acetate may help prevent or manage CINV, but those studies have important limitations. — Megestrol acetate versus dexamethasone to prevent nausea and vomiting in patients with gastric or gastro-oesophageal junction cancer treated with oxaliplatin-based chemotherapy: study protocol of a multicentre, randomised, non-inferiority trial
• Mechanistic evidence suggests megestrol acetate may reduce emesis by affecting 5-HT3 receptor-mediated signalling. — Megestrol acetate versus dexamethasone to prevent nausea and vomiting in patients with gastric or gastro-oesophageal junction cancer treated with oxaliplatin-based chemotherapy: study protocol of a multicentre, randomised, non-inferiority trial
• Megestrol acetate may reduce 5-HT3 expression and proinflammatory cytokines such as interleukin-1 and tumour necrosis factor alpha. — Megestrol acetate versus dexamethasone to prevent nausea and vomiting in patients with gastric or gastro-oesophageal junction cancer treated with oxaliplatin-based chemotherapy: study protocol of a multicentre, randomised, non-inferiority trial