Mendelian Randomisation
Cross-source consensus on Mendelian Randomisation from 1 sources and 4 claims.
1 sources · 4 claims
How it works
Benefits
Evidence quality
Highlighted claims
- Mendelian randomisation uses randomly allocated genetic variants at conception to infer causal effects of modifiable exposures on outcomes. — Cohort profile: the Mendelian randomisation in pregnancy (MR-PREG) collaboration – improving evidence for prevention and treatment of adverse pregnancy and perinatal outcomes
- MR depends on instruments being associated with the exposure, independent of confounders, and affecting outcomes only through the exposure. — Cohort profile: the Mendelian randomisation in pregnancy (MR-PREG) collaboration – improving evidence for prevention and treatment of adverse pregnancy and perinatal outcomes
- MR can reduce confounding from socioeconomic, behavioural, and health-related factors that affect conventional observational analyses. — Cohort profile: the Mendelian randomisation in pregnancy (MR-PREG) collaboration – improving evidence for prevention and treatment of adverse pregnancy and perinatal outcomes
- Drug target MR uses genetic proxies for drug targets to evaluate likely medication effects. — Cohort profile: the Mendelian randomisation in pregnancy (MR-PREG) collaboration – improving evidence for prevention and treatment of adverse pregnancy and perinatal outcomes