Methylation

Uses

How it works

Benefits

Dosage & preparation

Risks & contraindications

Interactions

Background

Evidence quality

Highlighted claims

• DNA methylation rate was measured as a baseline and then daily across a structured 3-day fasting experiment. — Blueprint Live Q&A: Plasma Exchange, Microplastics, Hair Regrowth, and Protocol Updates
• Methylation occurs billions of times per second in the human body and regulates gene expression, cancer prevention, neurotransmitter metabolism, and liver detoxification. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• SAMe is the master methyl donor used across all methylation reactions in the body. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• Methylation is a biochemical process central to DNA repair, detoxification, and neurotransmitter production. — What Happens When You Eat 3 to 4 Eggs Daily?
• Supplement and treatment decisions for methylation should be driven by physiological biomarkers such as homocysteine, not SNP results alone. — Nitric Oxide, Methylation, and the Microbiome: A Clinical Integration Framework
• Bryan Johnson's speed of aging showed no measurable change during a 3-day fast. — Blueprint Live Q&A: Plasma Exchange, Microplastics, Hair Regrowth, and Protocol Updates
• One in three Americans carries a deleterious MTHFR variant. — Nitric Oxide, Methylation, and the Microbiome: A Clinical Integration Framework
• Methylation dysfunction directly affects nitric oxide production via BH4 and glutathione. — Nitric Oxide, Methylation, and the Microbiome: A Clinical Integration Framework
• MTHFR genetic variants reduce the conversion of folate to its active methylated form, impairing overall methylation capacity. — Menopause, the Gut-Estrogen Axis, and Methylation: A Clinical Guide
• For individuals with impaired methylation, dietary choline, natural B12, and folate from eggs become critical because internal synthesis cannot compensate. — What Happens When You Eat 3 to 4 Eggs Daily?