Molecular Prototype Construction

How it works

Evidence quality

Highlighted claims

• Prototypes are built per organ because molecular concepts differ substantially across tissue types. — Bridging the Modality Bottleneck in Pathology MIL through Virtual Molecular Staining
• The key architectural choice is that clustering is performed in gene expression space to discover molecular states, but each prototype resides in morphological feature space to directly condition H&E patch embeddings. — Bridging the Modality Bottleneck in Pathology MIL through Virtual Molecular Staining
• The prototype bank is computed once per organ and stored offline, making it reusable without recomputation. — Bridging the Modality Bottleneck in Pathology MIL through Virtual Molecular Staining
• H&E-only clustering for prototypes recovers only half the performance gain of full cross-modal prototypes, confirming that molecular discovery rather than extra projection capacity drives the core improvement. — Bridging the Modality Bottleneck in Pathology MIL through Virtual Molecular Staining
• Performance degrades consistently at K=64 prototypes, suggesting that only a compact set of molecular concepts is necessary to span the molecular axes accessible from H&E. — Bridging the Modality Bottleneck in Pathology MIL through Virtual Molecular Staining