mTOR

Cross-source consensus on mTOR from 1 sources and 3 claims.

1 sources · 3 claims

How it works

mTOR is part of the downstream oncogenic signaling activated by IGF-1R. — An Analytical Approach for Insulin-like Growth Factor Receptor 1 and Mammalian Target of Rapamycin Blockades in Ewing Sarcoma
Combined inhibition of IGF-1R and mTOR has been reported to triple response rates compared with IGF-1R inhibition alone. — An Analytical Approach for Insulin-like Growth Factor Receptor 1 and Mammalian Target of Rapamycin Blockades in Ewing Sarcoma
The reported benefit of IGF-1R and mTOR co-inhibition supports the idea that feedback structures can be made more fragile by multi-target blockade. — An Analytical Approach for Insulin-like Growth Factor Receptor 1 and Mammalian Target of Rapamycin Blockades in Ewing Sarcoma