mTORC1
Cross-source consensus on mTORC1 from 1 sources and 5 claims.
1 sources · 5 claims
How it works
Evidence quality
Highlighted claims
- mTORC1 is framed as a central hub linking nutrients and growth signals to translation, autophagy, and ribosome production. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Amino acid deprivation inhibits mTORC1 and promotes autophagy and protein degradation to replenish amino acid pools. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Rag GTPases recruit mTORC1 to lysosomes, and GTP-bound Rheb activates mTORC1. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- Leucine and arginine are highlighted as especially important amino acids for mammalian mTORC1 activation. — Stress-induced Eukaryotic Translational Regulatory Mechanisms
- The role of amino acids beyond leucine, arginine, and methionine in mTORC1 activation remains unresolved. — Stress-induced Eukaryotic Translational Regulatory Mechanisms