Mutant Burden
Cross-source consensus on Mutant Burden from 1 sources and 6 claims.
1 sources · 6 claims
How it works
Benefits
Comparisons
Highlighted claims
- The total expected cell burden can still grow without bound when mutants escape replication limits. — Cellular replication limits in the Luria-Delbrück mutation model
- For k=50 and mutation probability 10^-9, the equal-growth asymptotic burden is about eight orders of magnitude smaller with limits. — Cellular replication limits in the Luria-Delbrück mutation model
- Replication limits can make total expected cell burden much smaller than in the no-limit model. — Cellular replication limits in the Luria-Delbrück mutation model
- Finite Hayflick limits can reduce expected long-term tumor burden by orders of magnitude. — Cellular replication limits in the Luria-Delbrück mutation model
- Variance under replication limits can differ from the expectation because it weights mutant growth with e to twice gamma times elapsed time. — Cellular replication limits in the Luria-Delbrück mutation model
- There are regimes where expected mutant counts are strongly affected while variance remains close to the no-limit prediction. — Cellular replication limits in the Luria-Delbrück mutation model