Non-Invasive Vagus Nerve Stimulation

How it works

Dosage & preparation

Preparation

Evidence quality

Highlighted claims

• The nVNS intervention uses the gammaCore Sapphire handheld device. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• Participants apply nVNS twice daily, with two 2-minute stimulations per session. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• The nVNS signal uses 5 kHz sine waves repeated at 25 Hz for a fixed duration of 2 minutes. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• The effect of non-invasive vagus nerve stimulation on the human glymphatic system has not yet been explored. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• Non-invasive vagus nerve stimulation is intended to inhibit cortical spreading depolarisations that may impair glymphatic flow. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial
• The trial expects an effect in CAA because CSD-related phenomena are common in that population. — Stimulating amyloid-β clearance in cerebral amyloid angiopathy with low-sodium oxybate and/or non-invasive vagus nerve stimulation (Clear-Brain): study protocol for a randomised pre-post trial