Nucleus Accumbens Deep Brain Stimulation

Uses

How it works

Benefits

Risks & contraindications

Comparisons

Evidence quality

Highlighted claims

• The nucleus accumbens participates in reward signaling, response inhibition, and dopaminergic reinforcement integration. — Electrical Stimulation of the Nucleus Accumbens for Severe, Refractory Self-Injurious Behaviour in Children (EASE-SIB): protocol for a randomised double-blinded crossover trial
• The prior phase I study found bilateral nucleus accumbens DBS was tolerated without serious adverse events in six children and adolescents. — Electrical Stimulation of the Nucleus Accumbens for Severe, Refractory Self-Injurious Behaviour in Children (EASE-SIB): protocol for a randomised double-blinded crossover trial
• The nucleus accumbens is considered a plausible neuromodulation target for severe automatically maintained SIB. — Electrical Stimulation of the Nucleus Accumbens for Severe, Refractory Self-Injurious Behaviour in Children (EASE-SIB): protocol for a randomised double-blinded crossover trial
• Nucleus accumbens DBS is described as the most common adult DBS target for obsessive-compulsive disorder. — Electrical Stimulation of the Nucleus Accumbens for Severe, Refractory Self-Injurious Behaviour in Children (EASE-SIB): protocol for a randomised double-blinded crossover trial
• Preclinical models suggest nucleus accumbens pathway activation can reduce repetitive and reward-seeking behaviours. — Electrical Stimulation of the Nucleus Accumbens for Severe, Refractory Self-Injurious Behaviour in Children (EASE-SIB): protocol for a randomised double-blinded crossover trial
• Phase I findings showed reductions in SIB and related behaviours after nucleus accumbens DBS. — Electrical Stimulation of the Nucleus Accumbens for Severe, Refractory Self-Injurious Behaviour in Children (EASE-SIB): protocol for a randomised double-blinded crossover trial