OIPN Pathophysiology
Cross-source consensus on OIPN Pathophysiology from 1 sources and 6 claims.
1 sources · 6 claims
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Highlighted claims
- Paclitaxel-induced and oxaliplatin-induced peripheral neuropathy resemble each other in clinical relevance but differ in their underlying biological mechanisms. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
- Acute OIPN is mainly caused by increased sensory nerve excitability driven by rapid calcium chelation and changes in voltage-gated sodium channels. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
- Chronic OIPN involves nuclear DNA damage in dorsal root ganglion cells, mitochondrial dysfunction, oxidative stress, and neuroinflammation caused by glial cell activation. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
- At the peripheral nerve level, chronic OIPN is linked to axonal transport defects, progressive axonal degeneration, ion channel hyperactivity, and neurovascular barrier disruption. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
- Hand compression may reduce neuronal peripheral exposure to oxaliplatin but is unlikely to prevent neuropathy mechanisms occurring at the dorsal root ganglion level, so it may not fully counteract OIPN. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
- More severe acute OIPN is associated with later development of chronic OIPN. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial